Journal article

Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction

F Andres, NJ Hannan, SP Walker, TM MacDonald, GP Wong, C Murphy, P Cannon, M Kandel, J Masci, TV Nguyen, A Abboud, D Idzes, V Kyritsis, N Pritchard, S Tong, TJ Kaitu’u-Lino

FASEB Journal | Published : 2022

Abstract

Placental dysfunction is the leading cause of both preeclampsia and fetal growth restriction. This study aimed to characterize endothelial protein C receptor (EPCR) in preterm preeclampsia, term preeclampsia, and fetal growth restriction (defined by delivery of a small for gestational age [SGA] infant [<10% birthweight centile]) and examine its regulation in primary syncytiotrophoblast. Placental EPCR mRNA and protein were significantly increased in patients with preterm preeclampsia (<34 weeks gestation) compared to gestation-matched controls (p <.0001). In the plasma, EPCR was also significantly elevated (p =.01) in established preterm preeclampsia while its substrate, protein C (PC) was s..

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